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UKEMS | |
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The University of Shizuoka, Shizuoka, Japan October 19-20, 2001 Following
the
success
of
2
earlier
workshops
(Melbourne,
1993;
Washington,
1999)
it
is
proposed
to
hold
a
follow-up
workshop
as
a
satellite
of
the
2001
International
Conference
on
Environmental
Mutagens,
Shizuoka,
Japan.
Three
assays
that
were
discussed
in
Washington
will
be
reviewed
for
further
clarification
of
recommendations,
and
2
new
groups
will
be
established. · Mouse lymphoma assay – measures and levels of cytotoxicity, use of conditioned medium, cleansing of cells, statistics, use of microwell vs agar techniques. · In vitro micronucleus assay – use of cytochalasin B, primary cells vs established cell lines, measures and levels of cytotoxicity, discrimination of aneugens and clastogens, equivalence of different cell types. · Transgenic genotoxicity models – treatment schedule, sampling times, size of experiment, data evaluation. · P53 and Hras2 transgenic tumour models – genetic/molecular characterisation required in animals, tissues and tumours before and after treatment. · Strategy and classification – development of an IARC-like classification system for genotoxins, a decision-tree approach to testing and classification, definition of risk categories.
Steering
committee: Correspondence: david.kirkland@covance.com or hayashi@nihs.go.jp Registration form can be found on IAEMS website www.iaems.nl
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