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Dr R. Steven Conlan |
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Steve lecturers in Genetics and has a research group focusing on transcription in eukaryotes. After graduating in Biology BSc (Hons) from Swansea in 1990, he undertook a PhD research degree at Wye College, University of London, U.K. and Long Ashton Research Station, Bristol, U.K. In 1993 he spent 6 months at the BBA in Braunschweig, Germany, funded by a British Council/DAAD studentship. After completing his PhD, Steve took up his first postdoctoral research position at the John Innes Centre in Norwich, U.K., and then in 1997 he took a postdoctoral position at IMBB in Heraklion, Crete, Greece before returning to Swansea Research Yeast transcription studies focus on the characterisation of the Ssn6 and Tup1 transcription repression complex, which regulates the transcription of a diverse array of genes. Specifically we are investigating the mechanisms driving repression. We have close links with the yeast DNA repair groups of Prof. Ray Waters, and Dr. Simon Reed at UWCM, Cardiff. Transcription and DNA repair are intimately linked processes, and the collaboration between the three groups will allow us to gain further insights into the communication between these two processes. Steve is also setting up a new plant molecular biology group to study mechanisms of transcription in higher plants. These studies will exploit the model plant system Arabidopsis thaliana, and the wealth of genome sequence data available culminating in the completion of the sequencing genome programme in 2000. Yeast Transcription R. Steven Conlan, Niki Gounalaki, Pantelis Hatzis, and Dimitris Tzamarias (1999). The Tup1-Cyc8 protein complex can shift from a transcriptional co-repressor to a transcription co-activator J. Biol. Chem. 274(1) 205-210 Manolis Papamichos-Chronakis, R. Steven Conlan, Niki Gounalaki, Tijana Copf, and Dimitris Tzamarias (2000). Hrs1/Med3 is a Cyc8-Tup1 corepressor target in the RNA polymerase II holoenzyme. J Biol Chem. 275(12):8397-403 Plant Transcription R. Steven Conlan, Michael Hammond-Kosack, and Michael Bevan (1999). Transcription activation mediated by the bZIP factor SPA on the endosperm box is modulated by ESBF-1 in vitro. Plant J. 19 (2) 173-181. Leo Galweiler, R. Steven Conlan, Patricia Mader, Jeff Schell, Klaus Palme, and Ian Moore (2000) DNA binding by Gal4 is sensitive to methylation of its binding site in plant chromatin. Plant J. 23(1) 143-157. Conlan RS, Griffiths L-A, Turner M, Fido R, Tatham A, Ainsworth CC, Shewry PR (1998) Characterisation of the yam tuber storage protein Dioscorin. J.Plant Physiol. 15 25-31. Albani D, Hammond-Kosack MCU, Smith C, Conlan S, Colot V, Holdsworth M, Bevan MW (1997). The wheat transcriptional activator SPA: A seed specific bZIP protein that recognises the GCN4-like motif in the bifactorial endosperm box of prolamin genes. Plant Cell (9) 171-184. Conlan RS, Griffiths L-A, Napier JA, Shewry PR, Mantell S, Ainsworth C (1995). Isolation and characterization of cDNA clones representing the genes encoding the major tuber storage protein (dioscorin) of yam (Dioscorea cayenensis lam). Plant Mol. Biol. 28 (3) 369-380. Teaching Society Memberships
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