The establishment of generic procedures for the activation of cryptic antibiotic biosynthetic pathways

Expression of a variety of heterologous cryptic pathways after their transfer to defined Superhost antibiotic production strains

Optimised expression of new antimicrobials, and engineered variants thereof, derived from activation of cryptic pathways, together with structural analysis and antimicrobial spectra

The establishment of refined genomic-based procedures for analysis of metagenomes to identify new antibiotic biosynthetic pathways

Expression of a variety of metagenomic pathways after their transfer to defined Superhost antibiotic production strains

Optimised expression of new antimicrobials, and engineered variants thereof, derived from metagenomic pathways, together with structural analysis and antimicrobial spectra

Optimised expression of new combinatorial antibiotics, together with structural analysis and antimicrobial spectra

Generic antibiotic production Superhosts derived by rational genomics-driven manipulation of Streptomyces coelicolor

Refined Superhosts strains optimised for production of key new antimicrobials

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