Foundation Biological Chemistry
The module will provide the student with a broad overview of biological chemistry in relation to molecules, their interactions and their roles within the human body. The module includes discussion of sugars, lipids, amino acids, DNA / RNA proteins and enzymes and provides the biological context of these molecules.The module is supported by 2 practical sessions and an essay submission with academic support.
Metabolism and Homeostasis
The module will provide the student with a broad overview of dietary requirements, digestion processes and associated anatomy, nutrient uptake and energetic metabolism processes within the human body. The catabolism of biomolecules for energy production will be covered and the role of the kidney in removal of by-products. The role of neuronal and hormonal systems in homeostatic control of the body will also be elaborated.
Foundation Applied Medical Sciences Skills Development 2
The module will provide the student with a diversity of laboratory and scientific skills in relation to the undertaking of undergraduate practical sessions in a safe manner and develop skills including molarity calculations, biological extractions, basic chromatography, an introduction into anatomical dissection and physiology.
Biochemistry Skills Development
This module is designed to develop the skills required for students of biochemistry and medical biochemistry. Students meet with their tutors and will be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy.
Joint session cover generic skills such as internet searching for scientific sources, referencing and plagiarism
Chemistry of Life
The module provides a broad study of the interactions between chemical processes and biological systems. It addresses the chemical processes used by organisms to utilize chemicals for energy production, structural functions and as building blocks of macromolecules.
Selected Medical Diagnostic Techniques
This module looks at the design and operation of a wide range of instrumentation used to make measurements for diagnostic and monitoring purposes. The emphasis is on the underlying electrical, mechanical, chemical, optical and other engineering principles.
Metabolic Regulation: Enzymes & Signal Transduction
This module reviews the basic elements of enzyme kinetics, including their mechanism and inhibition. The control of enzyme function by allosteric mechanisms is considered together with an appreciation of the significance of sigmoid kinetics. An overview of coenzymes and (metal) co-factors in enzyme function is given together with a description of the role played by vitamins in co-enzyme production. The module concludes with an overview of enzymes from extremophiles and their applications.
Biochemistry Skills Development II
This module is designed to develop the skills required for students of biochemistry. Students meet with tutors and will be given a series of assignments designed to develop skills in key areas including essay writing, presentation and analysis of research papers.
Datblygu Sgiliau Biocemeg II
Nod y modiwl hwn yw datblygu'r sgiliau mae eu hangen ar fyfyrwyr biocemeg. Bydd myfyrwyr yn cwrdd â thiwtoriaid ac yn derbyn cyfres o aseiniadau at ddiben datblygu eu sgiliau mewn meysydd allweddol, gan gynnwys ysgrifennu traethodau, cyflwyno a dadansoddi papurau ymchwil.
Amino acids, lipids and steroids
The module reviews the pathways of fatty acid degradation (beta-oxidation) before describing the biochemistry of the multi-functional proteins that catalyse the formation of fatty acids. The mechanisms of fatty acid elongation and desaturation are covered along with the synthesis of triacylglycerols and glycerophospholipids with consideration being being given to the control of these pathways.
The synthesis of cholesterol via the mevalonate pathway is described along with the various metabolic control points and an understanding of dietary lipid transport. The further metabolism of cholesterol to bile salts, steroid hormones and vitamin D is outlined with consideration given to the stereochemistry of these compounds.
The module provides a sound basis for understanding the metabolism of amino acids, lipids and steroids. The pathways of amino acid synthesis and degradation in humans are described along with an introduction to the urea cycle.
Techniques in Molecular Biology
The module will provide a sound theoretical and practical basis to a comprehensive range of biomolecular techniques currently employed in molecular genetics and biochemistry. Particular emphasis is placed on DNA recombinant technology, next generation sequencing, transcriptomics, proteomics and mass spectrometry.
Technegau Bioleg Foleciwlaidd
Bydd y modiwl yn darparu sylfaen ddamcaniaethol ac ymarferol gref ar gyfer ystod gynhwysfawr o dechnegau biofoleciwlaidd a ddefnyddir ar hyn o bryd mewn geneteg foleciwlaidd a biocemeg. Rhoir pwyslais penodol ar dechnoleg ailgyfuno DNA, dilyniannu cenhedlaeth nesaf, transgriptomeg, proteomeg a sbectrometreg màs.
Biomolecular Research Project
Nucleic acids: components, metabolism and modification
The module provides an understanding of the metabolism of nucleic acids and the biological relevance of their natural modification. The use of modified nucleic acid products clinically is also covered.
Biochemistry Literature Review and Communication
Students will acquire a detailed knowledge of one topical research area of key importance to their particular degree scheme.
Biomedical Laboratory Techniques
The module will provide practical and in depth theory of applications and equipment available to MSci students in the biomedical research laboratories based at the Medical School. The module will provide guidelines and rationale for experimental design, and data and statistical analysis.
Omics Techniques and their Application to Genomic Medicine
This module explores the state of the art genomics techniques used for DNA sequencing (e.g. targeted approaches, whole exome and whole genome sequencing) and RNA sequencing, using highly parallel techniques, together with current technologies routinely used to investigate genomic variation in the clinical setting. This module will introduce the bioinformatics approaches required for the analysis of genomic data, which together with data governance covered in Module 1 will provide a solid foundation for the Bioinformatics and Statistics module. The module will also cover the use of array based methodologies and RNA sequencing in estimating levels of protein expression, micro RNAs and long non¿ coding RNAs. A comprehensive introduction to metabolomics and proteomics, which are important for the functional interpretation of genomic data and discovery of disease biomarkers will also be included. Students will also learn about the strategies employed to evaluate pathogenicity of variants for clinical reporting.
Separation science and sample handling
This module covers the basic concepts of separation science, from analyte extraction through chromatographic separation, sample handling and ultimately to mass spectrometry-based detection. The module will focus on the application of separation science for the analysis of biomolecules isolated from complex mixtures.
LC/MS Applications IV: Medical and life sciences
Students will have the opportunity to gain extensive knowledge of the role mass spectrometry plays in biomarker discovery (proteins and small molecules).with its application to clinical diagnosis including the analysis of carbohydrates, glycoproteins and nucleic acids using activity-based proteomics and techniques for affinity pull-down.