Medicine - Research
Swansea University Medical School
Telephone: (01792) 295127
Room: Postdoctoral Research Office - 228
Second Floor
Institute of Life Science 1
Singleton Campus

I am a research officer in the research team of Dr Spyridon Theofilopoulos.

I hold a BSc in Genetics and a Health and Care Research Wales funded PhD in Medical and Health Care Studies both from Swansea University. My PhD focused on the function of innate immune receptors in gestation associated tissues. This has led to a long-standing interest on the role innate immunity in health and disease, particularly relating to the inflammasome and IL-1 family cytokines.

My current research involves identifying the function and mechanism of action of cholesterol metabolites, up- or down-regulated in Parkinson’s disease (PD) patients. Any newly identified neuroprotective agents will be examined to determine if they can prevent or rescue phenotypic features of PD in models of PD.

Further to my research role, I also contribute to teaching at different levels across the medical school.

Areas of Expertise

  • Innate Immunity
  • Inflammation
  • Placental Inflammation & Immunology

Publications

  1. & Expression and function of NOD-like receptors by human term gestation-associated tissues. Placenta 58, 25-32.
  2. & Production and regulation of interleukin-1 family cytokines at the materno-fetal interface. Cytokine 99, 194-202.
  3. & Human gestation-associated tissues express functional cytosolic nucleic acid sensing pattern recognition receptors. Clinical & Experimental Immunology
  4. & Interleukin 4 and interleukin 13 downregulate the lipopolysaccharide-mediated inflammatory response by human gestation-associated tissues†. Biology of Reproduction 96(3), 576-586.
  5. & Functional activity but not gene expression of toll-like receptors is decreased in the preterm versus term human placenta. Placenta

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Teaching

  • PM-132C Bioleg Celloedd Ewcaryotig

    Bydd y modiwl hwn yn darparu cyflwyniad bras i gysyniadau sylfaenol ym maes bioleg celloedd Ewcaryotig, gan ymchwilio i darddiad y gell, strwythur y gell a chelloedd arbenigol a chelloedd mewn clefyd. Bydd ffocws cyffredinol ar gelloedd dynol drwy gydol y modiwl, gan gyfeirio at organebau eraill yn ôl yr angen. Bydd myfyrwyr yn cael profiad ymarferol o nodi celloedd, gwahaniaethu rhwng gwahanol gelloedd dynol a rhywogaethau o anifeiliaid.

  • PM-141 Human Physiology II

    This module aims to provide students with further understanding of human physiology through studies on systems physiology including the endocrine, renal, blood, digestive/metabolism and reproductive system. The module will equally describe how malfunction of physiological systems gives rise to disease, using specific examples to enable students to appreciate the relationship between physiology/anatomy and medicine. Fundamental principles of physiology will be illustrated with appropriate clinical examples and during practical assignments.

  • PM-259 Contemporary themes and techniques in medical sciences

    This module aims to give students an overview of current and emerging themes in medical sciences, both from clinical and laboratory perspectives. This will cover topics generating high media interest, such as the zika virus and alternative methods of transplantation as well as new laboratory techniques. In addition, the module will be supported by two practical classes for which students will be required to conduct mini-projects based around the identification of patient samples and how these are presented as research cases. The module will also involve a one-day "conference", during which students will present data while experiencing a research conference atmosphere.

  • PM-352 Reproductive Biology and Medicine

    This module is designed to provide students with knowledge of the biochemistry, physiology and pathology of human pregnancy, fetal development, parturition and menopause. Particular focus will be given to fertility treatments and pharmacological interventions of menopause. Lectures will cover a recap of endocrinology of reproduction, and provide details of assisted reproductive technologies. Lectures will be supported by case studies which include current clinical approaches used to treat infertility and menopause.